DBCO-PEG5-NHS ester,95.06%
产品编号:Bellancom-126885| CAS NO:2144395-59-3| 分子式:C36H43N3O11| 分子量:693.74
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DBCO-PEG5-NHS ester
产品介绍 | DBCO-PEG5-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类,用于合成一系列 PROTAC 分子。DBCO-PEG5-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体活性分子结合物 (ADCs) 的合成。 | ||||||||||||||||
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生物活性 | DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | ||||||||||||||||
体外研究 |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 | |||||||||||||||||
体内研究 | |||||||||||||||||
性状 | Oil | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (144.15 mM) * "≥" means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
参考文献 |