Bucillamine SA96; Thiobutarit|cas:65002-17-7|西域试剂

Bucillamine SA96; Thiobutarit,98.87%

产品编号：Bellancom-118530| CAS NO：65002-17-7| 分子式：C₇H₁₃NO₃S₂| 分子量：223.31

布西拉明（SA96）是一种口服活性和有效的巯基供体和抗氧化剂。布西拉明也是一种具有抗血管生成特性的抗风湿剂。布西拉明可以保护高危器官移植中的缺血/再灌注损伤。布西拉明抑制VEGF的产生。布西拉明可用于研究脉络膜新生血管（CNV）和类风湿性关节炎（RA）。

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货号	价格	库存与货期
Bellancom-118530	￥700.00	杭州北京（现货）
Bellancom-118530	￥1150.00	杭州北京（现货）
Bellancom-118530	￥1900.00	杭州北京（现货）

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Bucillamine SA96; Thiobutarit

产品介绍

Bucillamine (SA96) 是一种口服有效的巯基供体和抗氧化剂 (antioxidant)。Bucillamine 也是一种抗风湿药 (antirheumatic agent)，具有抗血管生成 (antiangiogenic) 的特性。Bucillamine 对高危器官移植的缺血再灌注 (I/R) 损伤有保护作用。Bucillamine 抑制 VEGF 的产生。Bucillamine 可用于脉络膜新生血管性疾病 (CNV) 和类风湿关节炎 (RA) 的研究。

生物活性

Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA).

体外研究

体内研究

Bucillamine significantly enhances survival and protected against hepatic injury in rats subjected to liver transplants.
Bucillamine (Subconjunctival injection) significantly reduces the leakage and size of experimental CNV in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 5 mg/mL (22.39 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.4781 mL	22.3904 mL	44.7808 mL
5 mM	0.8956 mL	4.4781 mL	8.9562 mL
10 mM	0.4478 mL	2.2390 mL	4.4781 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. Amersi F, et al. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8915-20. [Content Brief]

. Yanagi Y, et al. Subconjunctival administration of bucillamine suppresses choroidal neovascularization in rat. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3495-9. [Content Brief]

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危害码 (欧洲)	T,N,Xi
风险声明 (欧洲)	R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
安全声明 (欧洲)	S26-S27-S28-S45-S60-S61
危险品运输编码	UN 3146 6.1/PG 3
WGK德国	3
包装等级	III
危险类别	6.1
海关编码	2930909090