Episilvestrol|cas:697235-39-5|西域试剂

Episilvestrol,99.86%

产品编号：Bellancom-15359| CAS NO：697235-39-5| 分子式：C₃₄H₃₈O₁₃| 分子量：654.66

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-15359		￥9900.00	杭州北京（现货）

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Episilvestrol

产品介绍

Episilvestrol 是 silvestrol 的衍生物，从 Aglaia perviridis 中分到，能够抑制 eIF4A 靶作用的转录过程。

生物活性

Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.

体外研究

Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED₅₀s of 3.8, 3.8, 5.5 and 15.3 nM, respectively. The GI₅₀s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (38.19 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5275 mL	7.6376 mL	15.2751 mL
5 mM	0.3055 mL	1.5275 mL	3.0550 mL
10 mM	0.1528 mL	0.7638 mL	1.5275 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式