Stepharine|cas:2810-21-1|西域试剂

Stepharine,98.0%

产品编号：Bellancom-N9347| CAS NO：2810-21-1| 分子式：C₁₈H₁₉NO₃| 分子量：297.35

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N9347		￥4200.00	杭州北京（现货）

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Stepharine

产品介绍

Stepharine 是天然的生物碱，可直接靶向 TLR4 (TLR4 抑制剂)，结合 TLR4/MD2 复合体。Stepharine 具有抗衰老、抗病毒和抗高血压等活性。

生物活性

Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects.

体外研究

Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells.
Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation.
Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Stepharine (500 μg/kg) inhibited NeuN⁺ cells loss and Iba-1⁺ cells increase in the MCAO ischemic cortex.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Middle cerebral artery occlusion (MCAO) rat model.
Dosage:	500 μg/kg (20 μL).
Administration:	Intranasally injected into rats 1h after MCAO.
Result:	Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.

体内研究

Stepharine (500 μg/kg) inhibited NeuN⁺ cells loss and Iba-1⁺ cells increase in the MCAO ischemic cortex.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Middle cerebral artery occlusion (MCAO) rat model.
Dosage:	500 μg/kg (20 μL).
Administration:	Intranasally injected into rats 1h after MCAO.
Result:	Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (84.08 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3630 mL	16.8152 mL	33.6304 mL
5 mM	0.6726 mL	3.3630 mL	6.7261 mL
10 mM	0.3363 mL	1.6815 mL	3.3630 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献