(R)-(+)-Dimethindene maleate|cas:136152-64-2|西域试剂

(R)-(+)-Dimethindene maleate,99.94%

产品编号：Bellancom-107647A| CAS NO：136152-64-2| 分子式：C₂₄H₂₈N₂O₄| 分子量：408.49

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货号	价格	库存与货期
Bellancom-107647A	￥1300.00	杭州北京（现货）
Bellancom-107647A	￥2200.00	杭州北京（现货）
Bellancom-107647A	￥4800.00	杭州北京（现货）
Bellancom-107647A	￥8200.00	杭州北京（现货）
Bellancom-107647A	￥14000.00	杭州北京（现货）

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(R)-(+)-Dimethindene maleate

产品介绍

(R)-(+)-Dimethindene maleate 是一种具有口服活性的 H₁-receptor 阻断剂，对猪具有抗组胺性能。

生物活性

(R)-(+)-Dimethindene maleate is an orally active H₁-receptor blocker with antihistaminic properties in pigs.

体外研究

(R)-(+)-Dimethindene maleate possesses membrane-stabilising effect.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

(R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED₅₀ of 2.73 mg/kg in pigs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male guinea-pigs
Dosage:	10 mL/kg
Administration:	Oral gavage, once
Result:	The ED₅₀-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED₅₀-value was found to be >31.6mg/kg. The oral LD₅₀-values was found to be 988 mg/kg.

体内研究

(R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED₅₀ of 2.73 mg/kg in pigs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male guinea-pigs
Dosage:	10 mL/kg
Administration:	Oral gavage, once
Result:	The ED₅₀-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED₅₀-value was found to be >31.6mg/kg. The oral LD₅₀-values was found to be 988 mg/kg.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (244.80 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4480 mL	12.2402 mL	24.4804 mL
5 mM	0.4896 mL	2.4480 mL	4.8961 mL
10 mM	0.2448 mL	1.2240 mL	2.4480 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

参考文献