STL1267|cas:1429024-58-7|西域试剂

STL1267,99.50%

产品编号：Bellancom-148711| CAS NO：1429024-58-7| 分子式：C₁₇H₁₁ClN₄O| 分子量：322.75

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货号	价格	库存与货期
Bellancom-148711	￥1000.00	杭州北京（现货）
Bellancom-148711	￥1700.00	杭州北京（现货）
Bellancom-148711	￥3500.00	杭州北京（现货）
Bellancom-148711	￥5800.00	杭州北京（现货）
Bellancom-148711	￥9200.00	杭州北京（现货）

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STL1267

产品介绍

STL1267 是一种有效的可穿过血脑屏障的 REV-ERB 激动剂，对 REV-ERBα 的K_i 值为 0.16 µM。STL1267 没有表现出细胞毒性。STL1267 抑制 BMAL1 的基因表达。

生物活性

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a K_i value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1.

体外研究

STL1267 (5 µM; 24 h) 在 HepG2 细胞中降低 BMAL1 的表达并增加 Mtnd1、Mtco1、Vicad、Lcad、Scad、Lkb1、Sirt1、Nampt、Ppargc1a 的基因表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HepG2, C2C12 cells
Concentration:	0-20 µM
Incubation Time:	24 h
Result:	Showed no adverse effects on cell viability up to the maximum dose examined 20 µM.

RT-PCR

Cell Line:	HepG2 cells
Concentration:	5 µM
Incubation Time:	24 h
Result:	Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a.

体内研究
(In Vivo)

STL1267 (50 mg/kg; i.p.; once) 在小鼠体内有效抑制 BMAL1 的表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks, male C57Bl/6 J mice
Dosage:	50 mg/kg
Administration:	I.p.; once
Result:	Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration.

体内研究

STL1267 (50 mg/kg; i.p.; once) 在小鼠体内有效抑制 BMAL1 的表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks, male C57Bl/6 J mice
Dosage:	50 mg/kg
Administration:	I.p.; once
Result:	Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration.

体内研究

STL1267 (50 mg/kg; i.p.; once) 在小鼠体内有效抑制 BMAL1 的表达。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks, male C57Bl/6 J mice
Dosage:	50 mg/kg
Administration:	I.p.; once
Result:	Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration.