KB-5492 free base|cas:113594-64-2|西域试剂

KB-5492 free base,99.06%

产品编号：Bellancom-47228| CAS NO：113594-64-2| 分子式：C₂₃H₃₀N₂O₆| 分子量：430.49

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货号	价格	库存与货期
Bellancom-47228	￥700.00	杭州北京（现货）
Bellancom-47228	￥1200.00	杭州北京（现货）
Bellancom-47228	￥2500.00	杭州北京（现货）
Bellancom-47228	￥4000.00	杭州北京（现货）
Bellancom-47228	￥6000.00	杭州北京（现货）

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KB-5492 free base

产品介绍

KB-5492 free base 是一种有效的和选择性的 sigma 受体抑制剂，抑制 [³H]1,3-di(2-tolyl)guanidine (DTG) 与 sigma 受体结合，IC₅₀ 值为 3.15 μM。KB-5492 free base 是一种抗溃疡剂。

生物活性

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [³H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC₅₀ of 3.15 μM. KB-5492 free base is an anti-ulcer agent.

体外研究

KB-5492 (0.001-100 μM) free base inhibits specific [³H]DTG binding in a concentration-dependent manner.
KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in ⁵¹Cr release from gastric epithelial cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage
Dosage:	200 mg/kg
Administration:	Oral gavage
Result:	Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.

体内研究

KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage
Dosage:	200 mg/kg
Administration:	Oral gavage
Result:	Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (232.29 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3229 mL	11.6147 mL	23.2293 mL
5 mM	0.4646 mL	2.3229 mL	4.6459 mL
10 mM	0.2323 mL	1.1615 mL	2.3229 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式