Dimethindene maleate|cas:3614-69-5|西域试剂

Dimethindene maleate,99.92%

产品编号：Bellancom-13710A| CAS NO：3614-69-5| 分子式：C₂₄H₂₈N₂O₄| 分子量：408.49

马来酸二甲酯是一种具有抗组胺作用的选择性组胺H1拮抗剂。马来酸二甲酯可用于超敏反应的研究。

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货号	价格	库存与货期
Bellancom-13710A	￥1200.00	杭州北京（现货）
Bellancom-13710A	￥1900.00	杭州北京（现货）
Bellancom-13710A	￥4000.00	杭州北京（现货）
Bellancom-13710A	￥6400.00	杭州北京（现货）
Bellancom-13710A	￥9800.00	杭州北京（现货）

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Dimethindene maleate

产品介绍

Dimethindene maleate 是一种选择性的 histamine H1 拮抗剂，具有抗组胺效应。Dimethindene maleate 可用于过敏性反应的研究。

生物活性

Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions.

体外研究

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K^＋ currents in a concentration-dependent and reversible manner with an IC₅₀ value of 29.5 μM.
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K^＋ currents with an IC₅₀ value of 49 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice with wound healing
Dosage:	0.25 mg
Administration:	Intraperitoneal injection; 0.25 mg once
Result:	Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.

体内研究

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice with wound healing
Dosage:	0.25 mg
Administration:	Intraperitoneal injection; 0.25 mg once
Result:	Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献

. Weller K, et, al. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006 Nov;20(13):2366-8. [Content Brief]

. Sakuta H. Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102. [Content Brief]

. Towart R, et al. Investigation of the antihistaminic action of dimethindene maleate (Fenistil) and its optical isomers. Agents Actions Suppl. 1991;33:403-8. [Content Brief]

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Dimethindene maleate,99.92%

Dimethindene maleate

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