LY266097 hydrochloride|cas:172895-39-5|西域试剂

LY266097 hydrochloride,99.60%

产品编号：Bellancom-103094| CAS NO：172895-39-5| 分子式：C₂₁H₂₄Cl₂N₂O₂| 分子量：407.33

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货号	价格	库存与货期
Bellancom-103094	￥440.00	杭州北京（现货）
Bellancom-103094	￥1450.00	杭州北京（现货）
Bellancom-103094	￥2150.00	杭州北京（现货）

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LY266097 hydrochloride

产品介绍

LY266097 hydrochloride 是一种选择性的 5-HT2B 受体拮抗剂，对 5-HT2A、5-HT2B、5-HT2C 的 pK_i 分别为 7.7、9.8 和 7.6。5-HT2B 受体阻断有助于抑郁症的研究。

生物活性

LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pK_is of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression.

体外研究

LY266097 is a highly selective 5-HT2B receptor antagonist with a pK_i of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity over human 5-HT2C and 5-HT2A sites.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

LY266097 (0.6 mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) .
The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 250-350 g
Dosage:	0.6 mg/kg
Administration:	Administered i.p. alone or concomitantly with Escitalopram (2 mg/kg) for 2 days
Result:	Short-term administration (0.6 mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 250-350 g
Dosage:	0.6 mg/kg
Administration:	Administered i.p. alone or concomitantly with Escitalopram (2 mg/kg) for 2 days
Result:	Short-term administration (0.6 mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.

性状

Solid

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (153.44 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4550 mL	12.2751 mL	24.5501 mL
5 mM	0.4910 mL	2.4550 mL	4.9100 mL
10 mM	0.2455 mL	1.2275 mL	2.4550 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (5.11 mM); Suspended solution; Need ultrasonic

此方案可获得 2.08 mg/mL (5.11 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明