Withanolide B|cas:56973-41-2|西域试剂

Withanolide B,99.0%

产品编号：Bellancom-129566| CAS NO：56973-41-2| 分子式：C₂₈H₃₈O₅| 分子量：454.60

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货号	价格	库存与货期
Bellancom-129566	￥850.00	杭州北京（现货）
Bellancom-129566	￥2500.00	杭州北京（现货）
Bellancom-129566	￥4000.00	杭州北京（现货）

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Withanolide B

产品介绍

Withanolide B 是 W. somnifera Dunal 的活性成分。Withanolide B 通过 ERK1/2 和 Wnt/β-catenin 信号通路促进 hBMSCs 的成骨分化。 Withanolide B 具有神经保护、抗关节炎、抗衰老和抗癌的作用。

生物活性

Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.

体外研究

Withanolide B (1-100 nM; 3-5 days) significantly increases the expression of COL1A1 and RUNX2 genes and proteins in hBMSCs.
Withanolide B (1-100 nM; 11 or 3 days) increases the formation of extracellular matrix calcium deposits and increased the activity of alkaline phosphatase (ALP).
Withanolide B (1-100 nM; 3-5 days) increases the protein expressions of p-ERK and active β-catenin of hBMSCs.
Withanolide B (10-100 μM; 48 h) reverses the Aβ42 aggregation-induced toxicy in SK-N-SH cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human bone mesenchymal stem cells
Concentration:	1, 10, 100 nM
Incubation Time:	3, 5 days
Result:	Significantly increased the expression of COL1A1 and RUNX2.

体内研究
(In Vivo)

Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect
Dosage:	10 mg/kg
Administration:	Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)
Result:	Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.

体内研究

Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect
Dosage:	10 mg/kg
Administration:	Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)
Result:	Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.

体内研究

Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect
Dosage:	10 mg/kg
Administration:	Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)
Result:	Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.