AN0128|cas:872044-70-7|西域试剂

AN0128,98.04%

产品编号：Bellancom-10979| CAS NO：872044-70-7| 分子式：C₂₀H₁₆BCl₂NO₃| 分子量：400.06

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-10979	￥1000.00	杭州北京（现货）
Bellancom-10979	￥1700.00	杭州北京（现货）
Bellancom-10979	￥3500.00	杭州北京（现货）
Bellancom-10979	￥5500.00	杭州北京（现货）
Bellancom-10979	￥9500.00	杭州北京（现货）

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AN0128

产品介绍

AN0128 是一种含硼的抗菌和抗炎剂。AN0128 对 S. aureus，S. epidermidis，P. acnes，B. subtilis 最低抑制浓度 (MIC) 值为 1、0.5、0.3、1 μg/mL。AN0128 可用于牙周病和皮肤病的研究。

生物活性

AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases.

体外研究

AN0128 (compound 2g; 10 μM; 24-48 hours) shows strong inhibition of the release of pro-inflammatory cytokines (TNF-α, IL-1β) but no inhibition of IFN-γ or IL-4 release in human peripheral blood mononuclear cells (PBMCs).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

AN0128 (1%, 5%; daily topical daub for 7 days) significantly reduces the formation of an inflammatory infiltrate and reduces bone loss.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)
Dosage:	1% AN0128 in 40% Transcutol P, 40% PBS, and 20% ethanol vehicle
Administration:	Daily topical daub for 7 days
Result:	Similar to Ketorolac, resulting 50% and 35% increase in bone area and bone volume respectively, and 38%, 42% decrease in bone loss and inflammation respectively.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)
Dosage:	5% with Total toothpaste
Administration:	Applied daily via a cotton-tip applicator. for 7 days
Result:	Had more effect than Total toothpaste, resulting in a 33% increase in bone volume, and a 47% decrease in bone loss.

体内研究

AN0128 (1%, 5%; daily topical daub for 7 days) significantly reduces the formation of an inflammatory infiltrate and reduces bone loss.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)
Dosage:	1% AN0128 in 40% Transcutol P, 40% PBS, and 20% ethanol vehicle
Administration:	Daily topical daub for 7 days
Result:	Similar to Ketorolac, resulting 50% and 35% increase in bone area and bone volume respectively, and 38%, 42% decrease in bone loss and inflammation respectively.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)
Dosage:	5% with Total toothpaste
Administration:	Applied daily via a cotton-tip applicator. for 7 days
Result:	Had more effect than Total toothpaste, resulting in a 33% increase in bone volume, and a 47% decrease in bone loss.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (312.45 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4996 mL	12.4981 mL	24.9963 mL
5 mM	0.4999 mL	2.4996 mL	4.9993 mL
10 mM	0.2500 mL	1.2498 mL	2.4996 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (5.20 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (5.20 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.20 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (5.20 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。