SHMT-IN-2|cas:2102681-49-0|西域试剂

SHMT-IN-2,99.50%

产品编号：Bellancom-129226| CAS NO：2102681-49-0| 分子式：C₂₂H₂₄F₃N₅O| 分子量：431.45

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货号	价格	库存与货期
Bellancom-129226	￥3000.00	杭州北京（现货）
Bellancom-129226	￥4800.00	杭州北京（现货）
Bellancom-129226	￥9500.00	杭州北京（现货）
Bellancom-129226	￥14500.00	杭州北京（现货）

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SHMT-IN-2

产品介绍

SHMT-IN-2 是一种特异性人SHMT1/2 抑制剂，对 SHMT1 和 SHMT2 的 IC₅₀ 值分别为 13 nM 和 66 nM。SHMT-IN-2 可以抑制许多人类癌细胞的生长，对 B 细胞淋巴瘤有敏感性。

生物活性

SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC₅₀ values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas.

体外研究

SHMT-IN-2 (compound 2) can inhibit cell growth with cellular IC₅₀ values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively.
SHMT-IN-2 (30 μM) shows the growth sensitivity with the median IC₅₀ was 4 μM to a panel of nearly 300 human cancer cell lines (with IC₅₀ values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (231.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3178 mL	11.5888 mL	23.1777 mL
5 mM	0.4636 mL	2.3178 mL	4.6355 mL
10 mM	0.2318 mL	1.1589 mL	2.3178 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献