CAIX Inhibitor S4|cas:1330061-67-0|西域试剂

CAIX Inhibitor S4,98.90%

产品编号：Bellancom-110243| CAS NO：1330061-67-0| 分子式：C₁₅H₁₇N₃O₄S| 分子量：335.38

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货号	价格	库存与货期
Bellancom-110243	￥700.00	杭州北京（现货）
Bellancom-110243	￥1200.00	杭州北京（现货）
Bellancom-110243	￥2500.00	杭州北京（现货）
Bellancom-110243	￥4500.00	杭州北京（现货）
Bellancom-110243	￥7500.00	杭州北京（现货）

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CAIX Inhibitor S4

产品介绍

CAIX Inhibitor S4 是一种有效和选择性的碳酸酐酶 IX/XII (CA IX/XII) 的抑制剂，K_i 值分别为 7 nM 和 2 nM。CAIX Inhibitor S4 还抑制 CA II 和 CA I (K_i=546 nM, 5600 nM)。CAIX Inhibitor S4 可以抑制原位 MDA-MB-231 小鼠模型中肺转移的数量，而不影响原发肿瘤的生长。

生物活性

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a K_i of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (K_i=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth.

体外研究

CAIX Inhibitor S4 (1-100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner.
CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration- dependent manner.
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	MDA-MB-231, HCT116 and HT29 cells
Concentration:	1, 10, 100 μM
Incubation Time:	24 hours
Result:	Inhibited the cell proliferation of MDA-MB-231, HCT116 and HT29 cells, with IC₅₀s of 481 μM, >1000 μM, and 20 μM, respectively.

体内研究
(In Vivo)

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells
Dosage:	10 mg/kg
Administration:	I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result:	Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors. The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

体内研究

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells
Dosage:	10 mg/kg
Administration:	I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result:	Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors. The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

体内研究

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells
Dosage:	10 mg/kg
Administration:	I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result:	Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors. The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (745.42 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9817 mL	14.9085 mL	29.8169 mL
5 mM	0.5963 mL	2.9817 mL	5.9634 mL
10 mM	0.2982 mL	1.4908 mL	2.9817 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式