5J-4|cas:827001-82-1|西域试剂

5J-4,95%

产品编号：Bellancom-110216| CAS NO：827001-82-1| 分子式：C₁₆H₁₂N₂O₃S| 分子量：312.34

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-110216		￥5600.00	杭州北京（现货）

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5J-4

产品介绍

5J-4 是一种有效的 CRAC 抑制剂。5J-4 减少了浸润到 CNS 中的单核细胞的数量，并显着减少浸润的 CD4+ 细胞。5J-4 可减轻炎症小鼠模型中 EAE (实验性自身免疫性脑脊髓炎) 的症状并延缓其发作。

生物活性

5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation.

体外研究

体内研究

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (MOG35-55 peptide-immunized mice)
Dosage:	2 m/kg
Administration:	I.p., every alternate day for 30 days
Result:	Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.

体内研究

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (MOG35-55 peptide-immunized mice)
Dosage:	2 m/kg
Administration:	I.p., every alternate day for 30 days
Result:	Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.