WR99210|cas:47326-86-3|西域试剂

WR99210,98.72%

产品编号：Bellancom-116387| CAS NO：47326-86-3| 分子式：C₁₄H₁₈Cl₃N₅O₂| 分子量：394.68

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-116387		￥2700.00	杭州北京（现货）
Bellancom-116387		￥8950.00	杭州北京（现货）

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WR99210

产品介绍

WR99210 是一种口服有效的、低毒的二氢叶酸还原酶 (DHFR) 抑制剂 (IC₅₀<0.075 nM)。WR99210 具有较好的抗寄生虫活性，能有效抑制间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine (HY-18062) 的恶性疟原虫株) 以及弓形虫。

生物活性

WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC₅₀<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii.

体外研究

WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture.
WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human foreskin fibroblasts (T. gondii-infected)
Concentration:	0-100 nM
Incubation Time:	92 h
Result:	Showed marked inhibition of T. gondii, with an IC₅₀ value of approximately 50 nM.

Cell Cytotoxicity Assay

Cell Line:	Human foreskin fibroblasts
Concentration:	0-100 nM
Incubation Time:	92 h
Result:	Lacked of toxicity for fibroblasts.

体内研究
(In Vivo)

WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male mice (T. gondii-infected).
Dosage:	1.25 mg/kg
Administration:	Intraperitoneal injection; single daily for 5 days.
Result:	Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.

体内研究

WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male mice (T. gondii-infected).
Dosage:	1.25 mg/kg
Administration:	Intraperitoneal injection; single daily for 5 days.
Result:	Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.

体内研究

WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male mice (T. gondii-infected).
Dosage:	1.25 mg/kg
Administration:	Intraperitoneal injection; single daily for 5 days.
Result:	Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.