R 59-022 hydrochloride DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride,98.88%
产品编号：Bellancom-107613A| CAS NO：93076-98-3| 分子式：C27H27ClFN3OS| 分子量：496.04
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R 59-022 hydrochloride DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride
| 产品介绍 | R 59-022 (DKGI-I) hydrochloride 是一种 DGK 抑制剂 (IC50: 2.8 µM)。R 59-022 hydrochloride 抑制 OAG 磷酸化为 OAPA。R 59-022 hydrochloride 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。 | |||||||||
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| 生物活性 | R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[4]. | |||||||||
| 体外研究 |
R 59-022 (10 μM，1 分钟) hydrochloride 增强血小板聚集。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[4]
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| 体内研究 (In Vivo) |
R 59-022 (2 mg/kg，腹腔注射，12 天) hydrochloride 显着增加植入 U87 GBM 细胞的 SCID 小鼠的中位生存期[6]。 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究 |
R 59-022 (2 mg/kg，腹腔注射，12 天) hydrochloride 显着增加植入 U87 GBM 细胞的 SCID 小鼠的中位生存期[6]。 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究 |
R 59-022 (2 mg/kg，腹腔注射，12 天) hydrochloride 显着增加植入 U87 GBM 细胞的 SCID 小鼠的中位生存期[6]。 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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| 性状 | Solid | |||||||||
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
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