CNDAC hydrochloride|cas:134665-72-8|西域试剂

CNDAC hydrochloride,99.59%

产品编号：Bellancom-16445B| CAS NO：134665-72-8| 分子式：C₁₀H₁₃ClN₄O₄| 分子量：288.69

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货号	价格	库存与货期
Bellancom-16445B	￥3500.00	杭州北京（现货）
Bellancom-16445B	￥5500.00	杭州北京（现货）
Bellancom-16445B	￥16500.00	杭州北京（现货）
Bellancom-16445B	￥22500.00	杭州北京（现货）

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CNDAC hydrochloride

产品介绍

CNDAC hydrochloride 是可口服试剂 Sapacitabine (HY-16445) 的代谢物，为核苷酸类似物。CNDAC hydrochloride 诱导 DNA 损伤和凋亡 (apoptosis)。

生物活性

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis.

体外研究

CNDAC 有一个独特的作用机制: 进入 DNA 后，它诱导单链断裂 (SSBs)，当细胞经历第二个 S 期时，单链断裂 (SSBs) 转化为双链断裂 (DSBs)。
缺乏 Rad51D 和 XRCC3 可使细胞对 CNDAC (0-1 μM; 24 h) 敏感。
CNDAC (0-100 μM; 3 days) 抑制 HL-60 和 THP-1 细胞的增殖。
CNDAC (0-10 μM; 3-6 days) 诱导 HL-60 和 THP-1 细胞的凋亡。
CNDAC (6 μM; 48 h) 诱导 HCT116 细胞在延迟 S 期后的 G2 期停止细胞周期。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cells
Concentration:	0-1 μM
Incubation Time:	24 h
Result:	Inhibited cell survival with IC₅₀s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.

Cell Proliferation Assay

Cell Line:	HL-60 and THP-1 cells
Concentration:	0-100 μM
Incubation Time:	3 days
Result:	Inhibited proliferation with IC₅₀s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.

Apoptosis Analysis

Cell Line:	HL-60 and THP-1 cells
Concentration:	0, 0.5, 1, 2, 3, 4, 5 and 10 μM
Incubation Time:	3, 4, 5, and 6 days
Result:	Induced apoptosis in both cells.

Cell Cycle Analysis

Cell Line:	HCT116
Concentration:	6 μM
Incubation Time:	48 h
Result:	36 and 36% of cells were arrested in late-S and G2/M phases, respectively.

体内研究
(In Vivo)

CNDAC (20mg/kg; i.p.; daily for 10 days) 显示小鼠抗肿瘤活性^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CDF1 mice, P388 tumor model^[4]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection, daily for 10 days
Result:	Greatly increased the survival time and survival rate.

体内研究

CNDAC (20mg/kg; i.p.; daily for 10 days) 显示小鼠抗肿瘤活性^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CDF1 mice, P388 tumor model^[4]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection, daily for 10 days
Result:	Greatly increased the survival time and survival rate.

体内研究

CNDAC (20mg/kg; i.p.; daily for 10 days) 显示小鼠抗肿瘤活性^[4]。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CDF1 mice, P388 tumor model^[4]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection, daily for 10 days
Result:	Greatly increased the survival time and survival rate.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (432.99 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4639 mL	17.3196 mL	34.6392 mL
5 mM	0.6928 mL	3.4639 mL	6.9278 mL
10 mM	0.3464 mL	1.7320 mL	3.4639 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献