Omadacycline tosylate 奥马环素; PTK 0796 tosylate; Amadacycline tosylate|cas:1075240-43-5|西域试剂

Omadacycline tosylate 奥马环素; PTK 0796 tosylate; Amadacycline tosylate,99.37%

产品编号：Bellancom-14865B| CAS NO：1075240-43-5| 分子式：C₃₆H₄₈N₄O₁₀S| 分子量：728.85

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货号	价格	库存与货期
Bellancom-14865B	￥2600.00	杭州北京（现货）
Bellancom-14865B	￥4500.00	杭州北京（现货）
Bellancom-14865B	￥15000.00	杭州北京（现货）

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Omadacycline tosylate 奥马环素; PTK 0796 tosylate; Amadacycline tosylate

产品介绍

Omadacycline (PTK 0796) tosylate，首创的具有口服活性的氨基甲基环素抗菌剂，是一种四环素类抗生素。Omadacycline tosylate 通过与 30S 核糖体亚基结合来抑制细菌蛋白质的合成。Omadacycline tosylate 对多种细菌表现出活性，包括好氧和厌氧革兰氏阳性细菌和革兰氏阴性细菌，非典型病原体。Omadacycline tosylate 可用于研究急性细菌性皮肤和皮肤结构感染，感染性肺炎和尿路感染。

生物活性

Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections^[4].

体外研究

Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC₉₀s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively.
Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED₅₀s ranging from 0.30 mg/kg to 3.39 mg/kg.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 12.5 mg/mL (17.15 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3720 mL	6.8601 mL	13.7202 mL
5 mM	0.2744 mL	1.3720 mL	2.7440 mL
10 mM	0.1372 mL	0.6860 mL	1.3720 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶