Piperaquine tetraphosphate tetrahydrate 四磷酸哌喹四水合物|cas:915967-82-7|西域试剂

Piperaquine tetraphosphate tetrahydrate 四磷酸哌喹四水合物,98.0%

产品编号：Bellancom-B1896B| CAS NO：915967-82-7| 分子式：C₂₉H₃₂Cl₂N₆.4H₃O₄P.4H₂O| 分子量：999.60

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货号	价格	库存与货期
Bellancom-B1896B	￥600.00	杭州北京（现货）
Bellancom-B1896B	￥900.00	杭州北京（现货）
Bellancom-B1896B	￥1800.00	杭州北京（现货）
Bellancom-B1896B	￥2800.00	杭州北京（现货）

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Piperaquine tetraphosphate tetrahydrate 四磷酸哌喹四水合物

产品介绍

Piperaquine tetraphosphate tetrahydrate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。

生物活性

Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin.

体外研究

体内研究

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t_1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites
Dosage:	0, 10, 30, 90 mg/kg
Administration:	A single i.p. administration
Result:	The median survival time was 10 days at dose of 10 mg/kg. The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.

Animal Model:	Male Swiss mice (6 weeks old)
Dosage:	90 mg/kg (Pharmacokinetic Analysis)
Administration:	A single i.p. administration
Result:	t_1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites
Dosage:	0, 10, 30, 90 mg/kg
Administration:	A single i.p. administration
Result:	The median survival time was 10 days at dose of 10 mg/kg. The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.

Animal Model:	Male Swiss mice (6 weeks old)
Dosage:	90 mg/kg (Pharmacokinetic Analysis)
Administration:	A single i.p. administration
Result:	t_1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.

性状

Solid

溶解性数据

In Vitro:

H₂O : 6 mg/mL (6.00 mM; Need ultrasonic)

DMSO : 5 mg/mL (5.00 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0004 mL	5.0020 mL	10.0040 mL
5 mM	0.2001 mL	1.0004 mL	2.0008 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献