NHC-diphosphate|cas:39023-73-9|西域试剂

NHC-diphosphate,98.80%

产品编号：Bellancom-135867D| CAS NO：39023-73-9| 分子式：C₉H₁₅N₃O₁₂P₂| 分子量：419.18

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货号	价格	库存与货期
Bellancom-135867D	￥3800.00	杭州北京（现货）
Bellancom-135867D	￥8000.00	杭州北京（现货）
Bellancom-135867D	￥12000.00	杭州北京（现货）

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NHC-diphosphate

产品介绍

NHC-diphosphate 是 NHC (HY-125033) 的活性胞内磷酸化代谢物 (intracellular metabolite)，以二磷酸盐的形式存在。NHC 是一种嘧啶核糖核苷，是一种有效的抗病毒剂 (anti-virus agent)。NHC 有效抑制委内瑞拉马脑炎病毒 (VEEV)、基孔肯亚病毒 (CHIKV) 和丙型肝炎病毒 (HCV) 的复制。

生物活性

NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV).

体外研究

Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.
Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite..

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 160 mg/mL (381.70 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3856 mL	11.9281 mL	23.8561 mL
5 mM	0.4771 mL	2.3856 mL	4.7712 mL
10 mM	0.2386 mL	1.1928 mL	2.3856 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献