MUT056399 Fab-001|cas:1269055-85-7|西域试剂

MUT056399 Fab-001,99.89%

产品编号：Bellancom-18169| CAS NO：1269055-85-7| 分子式：C₁₅H₁₃F₂NO₃| 分子量：293.27

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-18169		￥2400.00	杭州北京（现货）
Bellancom-18169		￥4000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

MUT056399 Fab-001

产品介绍

MUT056399 (Fab-001) 高效抑制金黄色葡萄球菌和大肠杆菌 FabI 酶, IC₅₀ 值分别为 12 nM 和 58 nM。

生物活性

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC₅₀s of 12 nM and 58 nM, respectively.

体外研究

MUT056399 (Fab-001) is a highly potent new inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli. MUT056399 is very active against S. aureus strains, including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), linezolid-resistant, and multidrug-resistant strains, with MIC90s between 0.03 and 0.12 μg/ml. MUT056399 is also active against coagulase-negative staphylococci, with MIC90s between 0.12 and 4 μg/ml. MUT056399 is very active against the 118 S. aureus strains tested, including MSSA and MRSA isolates and linezolid-resistant and multidrug-resistant strains, with MIC90s between ≤0.03 and 0.12 μg/ml.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

MUT056399 (Fab-001), administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day). In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 31 mg/mL (105.70 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4098 mL	17.0491 mL	34.0983 mL
5 mM	0.6820 mL	3.4098 mL	6.8197 mL
10 mM	0.3410 mL	1.7049 mL	3.4098 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式