LDC4297 hydrochloride|cas:2319747-14-1|西域试剂

LDC4297 hydrochloride,98.25%

产品编号：Bellancom-12653A| CAS NO：2319747-14-1| 分子式：C₂₃H₂₉ClN₈O| 分子量：468.98

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货号	价格	库存与货期
Bellancom-12653A	￥850.00	杭州北京（现货）
Bellancom-12653A	￥1440.00	杭州北京（现货）
Bellancom-12653A	￥3000.00	杭州北京（现货）
Bellancom-12653A	￥5000.00	杭州北京（现货）
Bellancom-12653A	￥8500.00	杭州北京（现货）

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LDC4297 hydrochloride

产品介绍

LDC4297 hydrochloride 是 CDK7 的选择性抑制剂，IC₅₀ 值为 0.13 nM。LDC4297 hydrochloride 抑制人巨细胞病毒 (HCMV) 复制，EC₅₀ 值为 24.5 nM。LDC4297 hydrochloride 具有广谱的抗病毒活性，对疱疹病毒，腺病毒，痘病毒，逆转录病毒和正粘病毒的 EC₅₀ 值为 0.02-1.21 μM。LDC4297 hydrochloride 可用于感染的研究。

生物活性

LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC₅₀ value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC₅₀ value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC₅₀ values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection.

体外研究

LDC4297 hydrochloride (0-10 μM; 6 d) dose-dependently inhibits HCMV replication with an EC₅₀ value of 24.5 nM.
LDC4297 hydrochloride (0-10 μM; 4 d) shows anti-proliferative activity to primary cultures of fibroblasts derived from human (HFF) with a GI₅₀ value of 4.5 μM.
LDC4297 hydrochloride (20 μM; 12-96 h) shows anti-HCMV activity through a multifaceted mode of action that involves an interference with virus-induced Rb phosphorylation.
LDC4297 hydrochloride (0-10 μM; 7 d) shows broad antiviral activities to HCMV, GPCMV, MCMV, HVV-6A, HSV-1, HSV-2, VZV, EBV, HAdV-2, Vaccinia virus, HIV-1 (nl4-3), HIV-1 (4LIG7) and Influenza A virus with EC₅₀ values of 0.02, 0.05, 0.07, 0.04, 0.02, 0.27, 0.06, 1.21, 0.25, 0.77, 1.04, 1.13 and 0.99 μM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Primary cultures of fibroblasts derived from human (HFF) with virus infection
Concentration:	20 μM
Incubation Time:	12, 24, 48 and 96 hours
Result:	Showed inhibitory effect towards viral protein synthesis at the stage of immediate early (IE) gene expression and the drug-mediated reduction of IE1p72 levels partially recovered over time. Exerted an inhibitory effect on human cytomegalovirus (HCMV) induced an up-regulation of protein expression or protein phosphorylation, and reduced Rb expression in the uninfected control cells at 24 h.

体内研究
(In Vivo)

LDC4297 hydrochloride (100 mg/kg; p.o. once) shows promising pharmacokinetic analyses.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD1 mice
Dosage:	100 mg/kg
Administration:	Oral gavage; 100 mg/kg once
Result:	Showed a half-life (t1/2z) of 1.6 h, and the time to a mean peak plasma concentration of 1297.6 ng/mL is reached 0.5 h after administration with a continued presence in plasma for at least 8 h and a bioavailability of 97.7%.

体内研究

LDC4297 hydrochloride (100 mg/kg; p.o. once) shows promising pharmacokinetic analyses.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD1 mice
Dosage:	100 mg/kg
Administration:	Oral gavage; 100 mg/kg once
Result:	Showed a half-life (t1/2z) of 1.6 h, and the time to a mean peak plasma concentration of 1297.6 ng/mL is reached 0.5 h after administration with a continued presence in plasma for at least 8 h and a bioavailability of 97.7%.

体内研究

LDC4297 hydrochloride (100 mg/kg; p.o. once) shows promising pharmacokinetic analyses.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD1 mice
Dosage:	100 mg/kg
Administration:	Oral gavage; 100 mg/kg once
Result:	Showed a half-life (t1/2z) of 1.6 h, and the time to a mean peak plasma concentration of 1297.6 ng/mL is reached 0.5 h after administration with a continued presence in plasma for at least 8 h and a bioavailability of 97.7%.