Stampidine|cas:217178-62-6|西域试剂

Stampidine,99.80%

产品编号：Bellancom-122470| CAS NO：217178-62-6| 分子式：C₂₀H₂₃BrN₃O₈P| 分子量：544.29

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-122470	￥4000.00	杭州北京（现货）
Bellancom-122470	￥6800.00	杭州北京（现货）
Bellancom-122470	￥13500.00	杭州北京（现货）

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Stampidine

产品介绍

Stampidine 是一种核苷逆转录酶抑制剂 (NRTI)，具有高效、广谱的抗 HIV 活性。Stampidine 抑制实验室 HIV-1 株 HTLV_IIIB (B 包膜亚型) 和主要临床分离株的 IC₅₀ 值分别为 1 nM 和 2 nM。Stampidine 还可以抑制耐 NRTI 临床分离株和耐 NNRTI 临床分离株，IC₅₀ 分别为 8.7 nM 和 11.2 nM 。

生物活性

Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

体外研究

Stampidine (7.8-1,000 μM; 24 hours) is not cytotoxic to genital tract epithelial cells.
Stampidine has no effect on sperm motility in cervical mucus.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Stampidine (50-100 mg/kg; p.o.) exhibits potent antiretroviral activity in chronically feline immunodeficiency virus (FIV)-infected cats.
Stampidine (100 mg/kg; p.o.) shows the average plasma C_max, AUC, half-life (t_1/2), and mean residence time (MRT) values of 15.4 µM, 23.1 µM•h, 108.6 min and 119.4 min, respectively, in dogs^[4].
Stampidine does not cause anemia, thrombocytopenia, neutropenia, or lymphopenia suggestive of hematologic toxicity, elevations of BUN or creatinine or electrolyte disturbances suggestive of renal toxicity or metabolic abnormalities, elevations of ALT, AST, Alk in adult beagle dogs^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SPF male or female domestic cats (2.9- 6.2 kg), with chronically FIV-infected
Dosage:	50 mg/kg, 100 mg/kg
Administration:	Oral administration (oral bolus dose)
Result:	Exhibited potent antiretroviral activity.

Animal Model:	Male beagle dogs (10-12 kg)^[4]
Dosage:	100 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral administration
Result:	The estimated average plasma C_max and AUC values were 15.4 µM and 23.1 µM·h, respectively. The average elimination half-life (t_1/2) and mean residence time (MRT) were 108.6 min and 119.4 min, respectively.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SPF male or female domestic cats (2.9- 6.2 kg), with chronically FIV-infected
Dosage:	50 mg/kg, 100 mg/kg
Administration:	Oral administration (oral bolus dose)
Result:	Exhibited potent antiretroviral activity.

Animal Model:	Male beagle dogs (10-12 kg)^[4]
Dosage:	100 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral administration
Result:	The estimated average plasma C_max and AUC values were 15.4 µM and 23.1 µM·h, respectively. The average elimination half-life (t_1/2) and mean residence time (MRT) were 108.6 min and 119.4 min, respectively.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (183.73 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8373 mL	9.1863 mL	18.3726 mL
5 mM	0.3675 mL	1.8373 mL	3.6745 mL
10 mM	0.1837 mL	0.9186 mL	1.8373 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 0.83 mg/mL (1.52 mM); Clear solution

此方案可获得 ≥ 0.83 mg/mL (1.52 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 0.83 mg/mL (1.52 mM); Clear solution

此方案可获得 ≥ 0.83 mg/mL (1.52 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 0.83 mg/mL (1.52 mM); Clear solution

此方案可获得 ≥ 0.83 mg/mL (1.52 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。