KDU731|cas:1610610-48-4|西域试剂

KDU731,98.0%

产品编号：Bellancom-103583| CAS NO：1610610-48-4| 分子式：C₂₂H₁₆N₆O₂| 分子量：396.40

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货号	价格	库存与货期
Bellancom-103583	￥5500.00	杭州北京（现货）
Bellancom-103583	￥9800.00	杭州北京（现货）
Bellancom-103583	￥15000.00	杭州北京（现货）

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KDU731

产品介绍

KDU731，具有口服活性的 C. parvum PI4K 抑制剂，阻断体内外隐孢子虫感染，IC₅₀ 值为 25 nM。KDU731 是研究隐孢子虫引起的腹泻的有望候选活性分子，具有广泛的安全性。

生物活性

KDU731, an orally active C. parvum PI4K inhibitor with an IC₅₀ value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety.

体外研究

体内研究

KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding.
KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts
Dosage:	7 or 10 mg/kg
Administration:	Orally administration; 7 or 10 mg/kg; 16 days
Result:	Resulted in significant reduction of oocyst shedding.

Animal Model:	Neonatal calves with 5 x 10⁷ oocysts
Dosage:	5 mg/kg
Administration:	Orally administration; 5 mg/kg; every 12 hours for 7 days
Result:	Resulted in significant reduction of oocyst shedding in treated calves in their stool.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts
Dosage:	7 or 10 mg/kg
Administration:	Orally administration; 7 or 10 mg/kg; 16 days
Result:	Resulted in significant reduction of oocyst shedding.

Animal Model:	Neonatal calves with 5 x 10⁷ oocysts
Dosage:	5 mg/kg
Administration:	Orally administration; 5 mg/kg; every 12 hours for 7 days
Result:	Resulted in significant reduction of oocyst shedding in treated calves in their stool.

性状

Solid

溶解性数据

In Vitro:

DMSO : 83.33 mg/mL (210.22 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5227 mL	12.6135 mL	25.2270 mL
5 mM	0.5045 mL	2.5227 mL	5.0454 mL
10 mM	0.2523 mL	1.2614 mL	2.5227 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式