Cecropin P1, porcine|cas:125667-96-1|西域试剂

Cecropin P1, porcine,99.87%

产品编号：Bellancom-P2317| CAS NO：125667-96-1| 分子式：C₁₄₇H₂₅₃N₄₅O₄₃| 分子量：3338.86

cecropinp1，pircine是一种抗菌肽，最初是在蛾类（Hyalophora cecropia）中鉴定出来的，后来在猪肠中鉴定出来。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-P2317		￥2900.00	杭州北京（现货）
Bellancom-P2317		￥6500.00	杭州北京（现货）

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Cecropin P1, porcine

产品介绍

Cecropin P1, porcine 是一种抗菌 (antibacterial) 肽，可从猪小肠上部分离。Cecropin P1, porcine 对革兰氏阴性菌具有抗菌活性。Cecropin P1, porcine 具有抗病毒 (antiviral) 活性，可抑制 PRRSV 感染。

生物活性

Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection.

体外研究

Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells.
Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation.
Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection.
Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Marc-145 cells
Concentration:	160, 320, and 480 μg/mL
Incubation Time:	36, 48, 72, 96 h
Result:	Significantly inhibited viral infection in a dose-dependent manner at 36 h postinfection. Inhibited CH-1a infection in Marc-145 cells with a 50% effective concentration (EC₅₀) of 112 μg/mL. The 50% cytotoxic concentration (CC₅₀) of Cecropin P1 for Marc-145 cells was estimated to be 719 μg/mL.

Western Blot Analysis

Cell Line:	Marc-145 cells
Concentration:	160, 320, and 480 μg/mL
Incubation Time:	36 h
Result:	Significantly inhibited viral infection in a dose-dependent manner at 36 h postinfection. Significantly reduced the expression of the viral N protein when administered with either the pre-, co-, or posttreatment method.

体内研究
(In Vivo)

Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (14.98 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2995 mL	1.4975 mL	2.9950 mL
5 mM	0.0599 mL	0.2995 mL	0.5990 mL
10 mM	0.0300 mL	0.1498 mL	0.2995 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

参考文献

. Andersson M, et al. Ascaris nematodes from pig and human make three antibacterial peptides: isolation of cecropin P1 and two ASABF peptides. Cell Mol Life Sci. 2003 Mar;60(3):599-606. [Content Brief]

. Guo C, et al. Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment. BMC Microbiol. 2014 Nov 18;14:273. [Content Brief]

. Giacometti A, et al. Effect of mono-dose intraperitoneal cecropins in experimental septic shock. Crit Care Med. 2001 Sep;29(9):1666-9. [Content Brief]

[4]. Jiang R, et al. Expression of antimicrobial peptide Cecropin P1 in Saccharomyces cerevisiae and its antibacterial, antiviral activity in vitro. Electronic Journal of Biotechnology, 2020.

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产品编号(Item Number)

批号(Lot Number)

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Cecropin P1, porcine,99.87%

Cecropin P1, porcine

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