Amikacin hydrate BAY 41-6551 hydrate|cas:1257517-67-1|西域试剂

Amikacin hydrate BAY 41-6551 hydrate,98.0%

产品编号：Bellancom-B0509| CAS NO：1257517-67-1| 分子式：C₂₀H₂₈N₂O₅S| 分子量：408.51

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货号	价格	库存与货期
Bellancom-B0509	￥500.00	杭州北京（现货）
Bellancom-B0509	￥800.00	杭州北京（现货）
Bellancom-B0509	￥2000.00	杭州北京（现货）

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Amikacin hydrate BAY 41-6551 hydrate

产品介绍

Amikacin hydrate (BAY 41-6551 hydrate) 是一种氨基糖苷类抗生素，也是一种卡那霉素的半合成类似物。Amikacin hydrate 具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。Amikacin hydrate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin hydrate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。

生物活性

Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria.

体外研究

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD₅₀ value of 453 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Fischer 344 rats (40-50-day-old)
Dosage:	320 mg/kg
Administration:	Subcutaneous injection; daily; for 10 days
Result:	Induced hearing loss in rats.

体内研究

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Fischer 344 rats (40-50-day-old)
Dosage:	320 mg/kg
Administration:	Subcutaneous injection; daily; for 10 days
Result:	Induced hearing loss in rats.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (244.79 mM; Need ultrasonic and warming)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4479 mL	12.2396 mL	24.4792 mL
5 mM	0.4896 mL	2.4479 mL	4.8958 mL
10 mM	0.2448 mL	1.2240 mL	2.4479 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式