KKL-10|cas:952849-76-2|西域试剂

KKL-10,98.0%

产品编号：Bellancom-101865| CAS NO：952849-76-2| 分子式：C₁₄H₁₀BrN₃O₂S| 分子量：364.22

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-101865	￥1300.00	杭州北京（现货）
Bellancom-101865	￥2080.00	杭州北京（现货）
Bellancom-101865	￥6650.00	杭州北京（现货）
Bellancom-101865	￥10640.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

KKL-10

产品介绍

KKL-10是一种具有广谱抗菌活性的小分子核糖体拯救抑制剂。

生物活性

KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

体外研究

The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 2.78 mg/mL (7.63 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7456 mL	13.7280 mL	27.4559 mL
5 mM	0.5491 mL	2.7456 mL	5.4912 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式