Narsoplimab OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)|cas:2108782-45-0|西域试剂

Narsoplimab OMS 721; Anti-MASP2 Reference Antibody (narsoplimab),95.00%

产品编号：Bellancom-P99376| CAS NO：2108782-45-0

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P99376		￥4200.00	杭州北京（现货）
Bellancom-P99376		￥10900.00	杭州北京（现货）

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Narsoplimab OMS 721; Anti-MASP2 Reference Antibody (narsoplimab)

产品介绍

Narsoplimab (OMS 721) 是一种高亲和力的全人免疫球蛋白γ 4 (IgG4) 单克隆抗体，可结合 MASP-2 并阻断凝集素通路激活。Narsoplimab 可用于造血干细胞移植和 SARS-CoV-2 的研究。

生物活性

Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.

体外研究

Narsoplimab (100 nM; 3 h; Vero E6 细胞和带有 SARS-CoV-2 的 Vero E6 细胞) 抑制了 N 蛋白增强的 MASP-2 沉积。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Narsoplimab (10 mg/kg; i.v.; WT and Masp2^-/- (KO) mice) 降低了小鼠淋巴细胞百分比 (Lym%)，增加了中性粒细胞百分比 (Neu%)。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	WT and Masp2^-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)
Dosage:	10 mg/kg
Administration:	Intravenous injection
Result:	Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).

体内研究

Narsoplimab (10 mg/kg; i.v.; WT and Masp2^-/- (KO) mice) 降低了小鼠淋巴细胞百分比 (Lym%)，增加了中性粒细胞百分比 (Neu%)。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	WT and Masp2^-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)
Dosage:	10 mg/kg
Administration:	Intravenous injection
Result:	Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).