TNIK-IN-3|cas:2754265-25-1|西域试剂

TNIK-IN-3,99.88%

产品编号：Bellancom-145293| CAS NO：2754265-25-1| 分子式：C₂₃H₁₈FN₃O₂| 分子量：387.41

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货号	价格	库存与货期
Bellancom-145293	￥4000.00	杭州北京（现货）
Bellancom-145293	￥6800.00	杭州北京（现货）
Bellancom-145293	￥13500.00	杭州北京（现货）

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TNIK-IN-3

产品介绍

TNIK-IN-3 (化合物 21k) 是一种有效，选择性和具有口服活性的 TNIK 抑制剂，IC₅₀ 值为 0.026 μM。TNIK-IN-3 还可以抑制 Flt4 (IC₅₀=0.030 μM)，Flt1 (IC₅₀=0.191 μM) 和 DRAK1 (IC₅₀=0.411 μM)。TNIK-IN-3 可用于结直肠癌的研究。

生物活性

TNIK-IN-3 is a potent, selective and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK), with an IC₅₀ of 0.026 μM. TNIK-IN-3 could also inhibit Flt4 (IC₅₀=0.030 μM), Flt1 (IC₅₀=0.191 μM) and DRAK1 (IC₅₀=0.411 μM). TNIK-IN-3 can be used for the research of colorectal cancer.

体外研究

TNIK-IN-3 (compound 21k) inhibits Aurora-A, GCK, and MLK3 with IC₅₀s of 0.517 μM, 3.657 μM, and 4.552 μM, respectively.
TNIK-IN-3 (0.1-100 μM; 3 days) inhibits the viability of HCT116 and DLD-1 cells, with IC₅₀s of 4.26 μM and 8.00 μM, respectively.
TNIK-IN-3 (2.5-40 μM; 10 days) dose-dependently inhibits the colony formation of HCT116 and DLD-1 cells.
TNIK-IN-3 (5-20 μM; 48 h) inhibits the migration of HCT116 and DLD-1 cells.
TNIK-IN-3 (5-40 μM; 48 h) dose-dependently inhibits the expression ofLRP5 and LRP6 proteins, Wnt target genes AXIN2 and c-Myc in HCT116 cells.
TNIK-IN-3 (5-20 μM; 48 h) significantly suppresses the phosphorylation of JNK1/2 in Hela cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HCT116 and DLD-1 cells
Concentration:	0.1-100 μM
Incubation Time:	3 days
Result:	Inhibited cell viability in a dose-dependent manner.

Cell Viability Assay

Cell Line:	HCT116 cells
Concentration:	5, 10, 20, 40 μM
Incubation Time:	48 hours
Result:	Inhibited the expression of Wnt target genes AXIN2 and c-Myc, LRP5 and LRP6 proteins.

体内研究
(In Vivo)

TNIK-IN-3 (compound 21k) (100-150 mg/kg; p.o. twice daily for 18 days) inhibits tumor growth in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old female NOD-SCID mice were injected with HCT116 cells
Dosage:	100, 150 mg/kg
Administration:	P.o. twice daily for 18 days
Result:	Significantly inhibited tumor growth at a dose of 150 mg/kg. No obvious weight loss and no other side effects were observed.

体内研究

TNIK-IN-3 (compound 21k) (100-150 mg/kg; p.o. twice daily for 18 days) inhibits tumor growth in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old female NOD-SCID mice were injected with HCT116 cells
Dosage:	100, 150 mg/kg
Administration:	P.o. twice daily for 18 days
Result:	Significantly inhibited tumor growth at a dose of 150 mg/kg. No obvious weight loss and no other side effects were observed.

体内研究

TNIK-IN-3 (compound 21k) (100-150 mg/kg; p.o. twice daily for 18 days) inhibits tumor growth in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old female NOD-SCID mice were injected with HCT116 cells
Dosage:	100, 150 mg/kg
Administration:	P.o. twice daily for 18 days
Result:	Significantly inhibited tumor growth at a dose of 150 mg/kg. No obvious weight loss and no other side effects were observed.

性状

Solid

溶解性数据

In Vitro:

DMSO : 83.33 mg/mL (215.10 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5812 mL	12.9062 mL	25.8124 mL
5 mM	0.5162 mL	2.5812 mL	5.1625 mL
10 mM	0.2581 mL	1.2906 mL	2.5812 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式