Niclofolan BAY 9015; Menichlopholan; Menichlofolan; Bilevon|cas:10331-57-4|西域试剂

Niclofolan BAY 9015; Menichlopholan; Menichlofolan; Bilevon

产品编号：Bellancom-113715| CAS NO：10331-57-4| 分子式：C₁₂H₆Cl₂N₂O₆| 分子量：345.09

尼古丁（BAY 9015）是一种口服活性驱虫剂。尼古丁可用于寄生虫感染的研究。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-113715	￥1000.00	杭州北京（现货）
Bellancom-113715	￥1600.00	杭州北京（现货）
Bellancom-113715	￥3200.00	杭州北京（现货）
Bellancom-113715	￥5100.00	杭州北京（现货）
Bellancom-113715	￥8100.00	杭州北京（现货）

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Niclofolan BAY 9015; Menichlopholan; Menichlofolan; Bilevon

产品介绍

Niclofolan (BAY 9015) 是一种具有口服活性的驱虫剂。Niclofolan 可用于寄生虫感染相关的研究。

生物活性

Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection.

体外研究

Niclofolan (0.12 mg/mL, 60 min) is effective against Gyrodactylus sp. under in vitro conditions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Gyrodactylus sp. (parasite)
Concentration:	0.12 mg/mL
Incubation Time:	60 min
Result:	Reduced the number of live Gyrodactylus sp. By 100%.

体内研究
(In Vivo)

Niclofolan (2 mg/kg, intramuscular injection) is effective against fasciola hepatica infected sheep.
Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	fasciola hepatica infected sheep
Dosage:	2 mg/kg
Administration:	Intramuscular injection
Result:	Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection.

Animal Model:	Rats infected with P.iloktsuenesis^[4]
Dosage:	1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times.
Administration:	Oral gavage
Result:	Reduced the worms in rats.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	fasciola hepatica infected sheep
Dosage:	2 mg/kg
Administration:	Intramuscular injection
Result:	Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection.

Animal Model:	Rats infected with P.iloktsuenesis^[4]
Dosage:	1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times.
Administration:	Oral gavage
Result:	Reduced the worms in rats.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	fasciola hepatica infected sheep
Dosage:	2 mg/kg
Administration:	Intramuscular injection
Result:	Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection.

Animal Model:	Rats infected with P.iloktsuenesis^[4]
Dosage:	1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times.
Administration:	Oral gavage
Result:	Reduced the worms in rats.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (289.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8978 mL	14.4890 mL	28.9779 mL
5 mM	0.5796 mL	2.8978 mL	5.7956 mL
10 mM	0.2898 mL	1.4489 mL	2.8978 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. T Eckhardt, Treatment of human fascioliasis with niclofolan. Gastroenterology. 1981 Oct; 81(4):795-8. [Content Brief]

. B H Ali, T Hassan, et al. The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. J Vet Pharmacol Ther. 1985 Dec;8(4):398-403. [Content Brief]

. Santamarina M. T., et al. Anthelmintic treatment against Gyrodactylus sp. infecting rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms, 1991 10(1): 39-43.

[4]. Rim H J, et al. Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis. The Korean Journal of Parasitology, 1976, 14(2): 140-146. [Content Brief]

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产品编号(Item Number)

批号(Lot Number)

Niclofolan BAY 9015; Menichlopholan; Menichlofolan; Bilevon

Niclofolan BAY 9015; Menichlopholan; Menichlofolan; Bilevon

化学品安全说明书(MSDS)

质检证书(COA)

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