Tivozanib hydrochloride hydrate AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate|cas:682745-41-1|西域试剂

Tivozanib hydrochloride hydrate AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate,99.88%

产品编号：Bellancom-10977A| CAS NO：682745-41-1| 分子式：C₂₂H₂₂Cl₂N₄O₆| 分子量：509.34

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货号	价格	库存与货期
Bellancom-10977A	￥790.00	杭州北京（现货）
Bellancom-10977A	￥1120.00	杭州北京（现货）
Bellancom-10977A	￥3170.00	杭州北京（现货）
Bellancom-10977A	￥5540.00	杭州北京（现货）

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Tivozanib hydrochloride hydrate AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate

产品介绍

Tivozanib hydrochloride hydrate 是一种有效的、选择性的、具有口服活性的 VEGFR 酪氨酸激酶 抑制剂，对 VEGFR-1、VEGFR-2、VEGFR-3的 IC₅₀ 值分别为 0.21、0.16、0.24 nM。Tivozanib hydrochloride hydrate 抑制肿瘤组织中的血管生成和血管通透性，并显示出抗肿瘤活性。Tivozanib hydrochloride hydrate 具有研究转移性肾细胞癌 (RCC) 的潜力。

生物活性

Tivozanib hydrochloride hydrate is a selective and orally active VEGFR tyrosine kinase inhibitor with IC₅₀ of 0.21, 0.16, 0.24 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. Tivozanib hydrochloride hydrate inhibits angiogenesis and vascular permeability in tumor tissues and shows antitumor activity. Tivozanib hydrochloride hydrate has the potential for the research of metastatic renal cell carcinoma (RCC).

体外研究

Tivozanib hydrochloride hydrate inhibits the phosphorylation of VEGFR-1, VEGFR-2 and VEGFR-3.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tivozanib hydrochloride hydrate (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tivozanib hydrochloride hydrate (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (490.83 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9633 mL	9.8166 mL	19.6333 mL
5 mM	0.3927 mL	1.9633 mL	3.9267 mL
10 mM	0.1963 mL	0.9817 mL	1.9633 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献