BM635|cas:1493762-74-5|西域试剂

BM635,99.85%

产品编号：Bellancom-109587| CAS NO：1493762-74-5| 分子式：C₂₅H₂₉FN₂O| 分子量：392.51

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货号	价格	库存与货期
Bellancom-109587	￥1100.00	杭州北京（现货）
Bellancom-109587	￥3300.00	杭州北京（现货）
Bellancom-109587	￥5500.00	杭州北京（现货）
Bellancom-109587	￥11000.00	杭州北京（现货）
Bellancom-109587	￥16500.00	杭州北京（现货）

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BM635

产品介绍

BM635是 MmpL3 的抑制剂，具有出色的抗分歧杆菌活性。抑制结合分歧杆菌H37Rv的MIC₅₀ 值为0.12 μM。

生物活性

BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC₅₀ of 0.12 μM against M. tuberculosis H37Rv.

体外研究

体内研究

BM635 has potent MIC (0.12 µM), Tox₅₀:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED₉₉ of 49 mg/Kg (IC_95%: 43–54 mg/Kg). The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (C_max=1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 31 mg/mL (78.98 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5477 mL	12.7385 mL	25.4771 mL
5 mM	0.5095 mL	2.5477 mL	5.0954 mL
10 mM	0.2548 mL	1.2739 mL	2.5477 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式