Cyclacillin (Wy-4508) is an orally active aminopenicillin antibiotic, shows antibacterial activity against a wide range of gram-positive and gram-negative pathogens.

Cyclacillin (0-125 μg/mL) inhibits varies pathogens except Klebsiella an Enterobacter organisms with MIC values range from 0.24 μg/mL to 7.8 μg/mL.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclacillin (0-287 mg/kg; p.o.; single dose) shows oral activity in mice and rescues mice injected with gram-positive and gram-negative pathogens.
Cyclacillin (10 mg/kg; i.v.; single dose) is absorbed by the rat intestinal tissue at relatively low concentrations (less than 1 mg/mL) followed solely Michaelis-Menten kinetics.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclacillin (0-287 mg/kg; p.o.; single dose) shows oral activity in mice and rescues mice injected with gram-positive and gram-negative pathogens.
Cyclacillin (10 mg/kg; i.v.; single dose) is absorbed by the rat intestinal tissue at relatively low concentrations (less than 1 mg/mL) followed solely Michaelis-Menten kinetics.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Warren GH. Cyclacillin: microbiological and pharmacological properties and use in chemotherapy of infection - a critical appraisal. Chemotherapy. 1976;22(3-4):154-82.  [Content Brief]