BMS-433771|cas:543700-68-1|西域试剂

BMS-433771,99.96%

产品编号：Bellancom-120632| CAS NO：543700-68-1| 分子式：C₂₁H₂₃N₅O₂| 分子量：377.44

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货号	价格	库存与货期
Bellancom-120632	￥6200.00	杭州北京（现货）
Bellancom-120632	￥7700.00	杭州北京（现货）
Bellancom-120632	￥11000.00	杭州北京（现货）

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BMS-433771

产品介绍

BMS-433771 是一种有效的呼吸道合胞病毒 (RSV) 抑制剂，具有口服活性。BMS-433771 对 A 组和 B 组 RSV 均有效， EC₅₀ 均值为 20 nM。BMS-433771 可用于呼吸道疾病的研究。

生物活性

BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC₅₀ of 20 nM. BMS-433771 can be used for the research of respiratory tract disease.

体外研究

BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC₅₀ of 20 nM.
BMS-433771 can inhibit viral F protein-induced membrane fusion.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models
.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	rodent models of RSV infection (cotton rat and mice)
Dosage:	1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration:	oral, single or bid 4 days
Result:	Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.

体内研究

BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models
.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	rodent models of RSV infection (cotton rat and mice)
Dosage:	1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration:	oral, single or bid 4 days
Result:	Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.