Almonertinib mesylate HS-10296 mesylate|cas:2134096-06-1|西域试剂

Almonertinib mesylate HS-10296 mesylate,99.85%

产品编号：Bellancom-112823A| CAS NO：2134096-06-1| 分子式：C₃₁H₃₉N₇O₅S| 分子量：621.75

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货号	价格	库存与货期
Bellancom-112823A	￥2500.00	杭州北京（现货）
Bellancom-112823A	￥4000.00	杭州北京（现货）
Bellancom-112823A	￥7500.00	杭州北京（现货）
Bellancom-112823A	￥10500.00	杭州北京（现货）
Bellancom-112823A	￥14500.00	杭州北京（现货）

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Almonertinib mesylate HS-10296 mesylate

产品介绍

Almonertinib (HS-10296) mesylate 是一种口服、不可逆的第三代 EGFR 酪氨酸激酶抑制剂，对 EGFR 致敏和 T790M 耐药突变具有高选择性。Almonertinib mesylate 对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性 (IC₅₀ 分别为 0.37、0.29 和 0.21 nM)，对野生型的抑制作用较弱 (3.39 nM)。Almonertinib mesylate 用于非小细胞肺癌的研究。

生物活性

Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer.

体外研究

HS-10296 mesylate is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC. Additionaly, HS-10296 mesylate could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 31.25 mg/mL (50.26 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6084 mL	8.0418 mL	16.0836 mL
5 mM	0.3217 mL	1.6084 mL	3.2167 mL
10 mM	0.1608 mL	0.8042 mL	1.6084 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献