Porcn-IN-1|cas:2036044-77-4|西域试剂

Porcn-IN-1,99.92%

产品编号：Bellancom-111472| CAS NO：2036044-77-4| 分子式：C₂₅H₁₉FN₄O| 分子量：410.44

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-111472		￥1500.00	杭州北京（现货）
Bellancom-111472		￥2500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Porcn-IN-1

产品介绍

Porcn-IN-1 是有效的 porcupine 抑制剂，IC₅₀ 值为 0.5±0.2 nM。

生物活性

Porcn-IN-1 is potent porcupine inhibitor with an IC₅₀ of 0.5±0.2 nM.

体外研究

Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (243.64 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4364 mL	12.1820 mL	24.3641 mL
5 mM	0.4873 mL	2.4364 mL	4.8728 mL
10 mM	0.2436 mL	1.2182 mL	2.4364 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式