JH-VIII-157-02|cas:1639422-97-1|西域试剂

JH-VIII-157-02,99.67%

产品编号：Bellancom-112140| CAS NO：1639422-97-1| 分子式：C₂₈H₂₇N₅O₂| 分子量：465.55

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-112140	￥5100.00	杭州北京（现货）
Bellancom-112140	￥8150.00	杭州北京（现货）
Bellancom-112140	￥15500.00	杭州北京（现货）

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JH-VIII-157-02

产品介绍

JH-VIII-157-02 是 alectinib 的结构类似物，为 ALK 抑制剂，对棘皮动物微管相关蛋白样 4 (EML4)-ALK G1202R 的 IC₅₀ 值为 2 nM。

生物活性

JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC₅₀ of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.

体外研究

JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC₅₀ of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. JH-VIII-157-02 also potently inhibits EML4-ALK^wt (Eawt), EAC1156Y, EAF1174L, EAS1206Y (IC₅₀, 2 nM), EAG1269A (IC₅₀, 3 nM), EAL1196M (IC₅₀, 58 nM), EA1151Tins (IC₅₀, 107 nM), and EAL1152R (IC₅₀, 196 nM). Moreover, JH-VIII-157-02 has selectivity at other kinases, including IRAK1, CLK4, RET, RET V804L, RET V804M and IRAK 4, and the IC₅₀s are 14 nM, 14 nM, 3 nM, 13 nM, 12 nM, and 465 nM respectively. JH-VIII-157-02 exhibits inhibitory growth of cancer cell lines, such as H3122, DFCI76 (L1152R] with EC₅₀s of 5, 19 nM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 25 mg/mL (53.70 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1480 mL	10.7400 mL	21.4800 mL
5 mM	0.4296 mL	2.1480 mL	4.2960 mL
10 mM	0.2148 mL	1.0740 mL	2.1480 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式