KIF18A-IN-2|cas:2600559-20-2|西域试剂

KIF18A-IN-2,99.34%

产品编号：Bellancom-145802| CAS NO：2600559-20-2| 分子式：C₂₅H₃₄N₄O₅S₂| 分子量：534.69

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-145802		￥5900.00	杭州北京（现货）
Bellancom-145802		￥8900.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

KIF18A-IN-2

产品介绍

KIF18A-IN-2 是一种有效的 KIF18A 抑制剂 (IC₅₀=28 nM)。KIF18A-IN-2 能引起明显的有丝分裂停滞，增加肿瘤组织中有丝分裂细胞的数量。KIF18A-IN-2 可用于肿瘤研究。

生物活性

KIF18A-IN-2 is a potent KIF18A inhibitor (IC₅₀=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.

体外研究

体内研究

KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours. Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice.

	IP (100 mg/kg)
C_max (μM)	12.6
AUC_0-24 (μM·h)	147
C_24h (μM)	2.9
PPB (f_u)	0.007

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)
Dosage:	100 mg/kg
Administration:	i.p., single
Result:	Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.

体内研究

	IP (100 mg/kg)
C_max (μM)	12.6
AUC_0-24 (μM·h)	147
C_24h (μM)	2.9
PPB (f_u)	0.007

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)
Dosage:	100 mg/kg
Administration:	i.p., single
Result:	Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.