Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC₅₀ = 0.12 μM). Hymeglusin covalently modifies the active Cys¹²⁹ residue of the enzyme.

Hymeglusin inhibits dengue type 2 (DEN-2) New Guinea C (NGC) live virus replication in K562 cells. The therapeutic index (CC₅₀/IC₅₀) of Hymeglusin is 11. The EC₅₀ of Hymeglusin in K562 cells is 4.5 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389(1-2):18-19.  [Content Brief]

  . Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92.  [Content Brief]

  . Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.  [Content Brief]