Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca²⁺ influx through voltage-gated Ca²⁺ channels, leading to the reduction in [Ca²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM.

• . Araújo IG, et al. Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin. Molecules. 2014 May 23;19(5):6863-76.  [Content Brief]

  . Jindaporn Puripattanavong, et al. Anti-allergic and anti-inflammatory compounds from Aglaia andamanica leaves. Songklanakarin J. Sci. Technol. 2015,37 (1), 37-41.