Apoptolidin,95.0%
产品编号：Bellancom-126679| CAS NO：194874-06-1| 分子式：C58H96O21| 分子量：1129.37
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Apoptolidin
| 产品介绍 | Apoptolidin 是从 Nocardiopsis 细菌中分离得到的一种聚酮类化合物。Apoptolidin 是一种选择性线粒体 F1FO ATPase 抑制剂。Apoptolidin 是一种凋亡 (apoptosis)诱导剂，可诱导腺病毒型 12 癌基因(包括ElA) (IC50=10-17 ng/ml) 转化的细胞凋亡，但不诱导正常细胞的凋亡。 | |||||||||
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| 生物活性 | Apoptolidin is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells. | |||||||||
| 体外研究 |
Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
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| 性状 | Solid | |||||||||
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
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