Bryostatin 1 苔藓抑素1|cas:83314-01-6|西域试剂

Bryostatin 1 苔藓抑素1

产品编号：Bellancom-105231| CAS NO：83314-01-6| 分子式：C₄₇H₆₈O₁₇| 分子量：905.03

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-105231		￥5200.00	杭州北京（现货）

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Bryostatin 1 苔藓抑素1

产品介绍

Bryostatin 1 是一种天然的大环内酯类化合物，从苔藓虫 Bugula neritina 中分离出来，也是一种有效的中枢神经系统 (CNS) 渗透性的 PKC 调节剂。Bryostatin 1 以 K_i 值为 8.07 nM 和 0.45 nM 分别结合到分离的 Munc13-1 的 C1 域和全长的 Munc13-1 蛋白。Bryostatin 1 具有抗癌，抗炎，神经保护，抗 HIV-1 感染的特性。

生物活性

Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties^[4].

体外研究

Bryostatin 1 (1 µM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation .
The increased level of expression of Munc13-1 following a 24 h incubation with Bryostatin 1 in both HT22 and primary mouse hippocampal cells is observed.
Bryostatin 1 can also affect the immune system by modulating dendritic cells (DCs) via toll-like receptor 4 (TLR4) through the MyD88-independent pathway, which favors an anti-inflammatory environment by inducing a type 2 phenotype that promotes the differentiation of CD4⁺ T-helper (Th) lymphocytes into Th2 versus Th1 effector cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HT22 cells
Concentration:	1 µM
Incubation Time:	5 minutes
Result:	Caused Munc13-1 to transfer to the membrane fraction.

体内研究
(In Vivo)

Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6J mice (8-12-week-old) with MOG_35-55
Dosage:	30 μg/kg
Administration:	Intraperitoneal injection; 3 d per week; for 2 weeks
Result:	Abolished the onset of experimental autoimmune encephalomyelitis (EAE).

体内研究

Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6J mice (8-12-week-old) with MOG_35-55
Dosage:	30 μg/kg
Administration:	Intraperitoneal injection; 3 d per week; for 2 weeks
Result:	Abolished the onset of experimental autoimmune encephalomyelitis (EAE).

体内研究

Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6J mice (8-12-week-old) with MOG_35-55
Dosage:	30 μg/kg
Administration:	Intraperitoneal injection; 3 d per week; for 2 weeks
Result:	Abolished the onset of experimental autoimmune encephalomyelitis (EAE).