Tribendimidine 三苯双脒,98.0%

产品编号:Bellancom-147360| CAS NO:115103-15-6| 分子式:C28H32N6| 分子量:452.59

三苯二胺是一种口服活性广谱驱虫剂,对蛔虫和美洲锥虫具有特别高的活性。三苯二胺也是一种L型烟碱乙酰胆碱受体(nAChR)激动剂。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用,

货号 包装 价格 库存与货期 购买量 操作
Bellancom-147360
600.00 杭州 北京(现货)
Bellancom-147360
1000.00 杭州 北京(现货)
Bellancom-147360
2000.00 杭州 北京(现货)
Bellancom-147360
3000.00 杭州 北京(现货)
Bellancom-147360
4500.00 杭州 北京(现货)

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Tribendimidine 三苯双脒

产品介绍 Tribendimidine 一种广谱的、具有口服活性的驱虫剂,对 A. lumbricoidesN. americanus 具有特别高的活性。Tribendimidine 也是 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。
生物活性

Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.

体外研究

Tribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans.
Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL.
Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine. .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C. sinensis infected Female Wistar rats
Dosage: 75 mg/kg and 150 mg/kg
Administration: Oral administration, once
Result: A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.
体内研究

Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C. sinensis infected Female Wistar rats
Dosage: 75 mg/kg and 150 mg/kg
Administration: Oral administration, once
Result: A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.
性状Solid
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (110.48 mM; ultrasonic and adjust pH to 3 with HCl)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2095 mL 11.0475 mL 22.0951 mL
5 mM 0.4419 mL 2.2095 mL 4.4190 mL
10 mM 0.2210 mL 1.1048 mL 2.2095 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.52 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液
  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.52 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.52 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 西域 网站选购。
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

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