UBE2T/FANCL-IN-1|cas:1359415-02-3|西域试剂

UBE2T/FANCL-IN-1,99.51%

产品编号：Bellancom-126539| CAS NO：1359415-02-3| 分子式：C₁₉H₃₁N₇| 分子量：357.50

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-126539		￥5000.00	杭州北京（现货）
Bellancom-126539		￥8000.00	杭州北京（现货）

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UBE2T/FANCL-IN-1

产品介绍

UBE2T/FANCL-IN-1 是 UBE2T/FANCL 介导的 FANCD2 单泛素化的有效抑制剂，可使细胞对DNA 交联剂卡铂敏感。

生物活性

UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin.

体外研究

UBE2T/FANCL-IN-1 (CU2) completely inhibits the ubiquitylation of GST-FANCLRING at 100 μM. UBE2T/FANCL-IN-1 (500 μM) reduced the level of mUb-FANCD2 in response to HU treatment. UBE2T/FANCL-IN-1 (500 μM) also reducesthe level of mUb-FANCD2 generated in response to Cisplatin (10 μM) treatment for 6, 12, and 24 hours. The combination of 250 μM UBE2T/FANCL-IN-1 with 15 μM carboplatin led to an even more pronounced decrease in cell proliferation/growth, with the cells being <50% confluent after 8 days.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式