C8-Ceramide N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine|cas:74713-59-0|西域试剂

C8-Ceramide N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine,98.0%

产品编号：Bellancom-108391| CAS NO：74713-59-0| 分子式：C₂₆H₅₁NO₃| 分子量：425.69

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性，能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。

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货号	价格	库存与货期
Bellancom-108391	￥950.00	杭州北京（现货）
Bellancom-108391	￥1650.00	杭州北京（现货）
Bellancom-108391	￥3600.00	杭州北京（现货）
Bellancom-108391	￥6300.00	杭州北京（现货）
Bellancom-108391	￥11000.00	杭州北京（现货）

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C8-Ceramide N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

产品介绍

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性，能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide在体外能轻微地诱导 PKC 活化。

生物活性

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro^[4].

体外研究

C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	CALO cells, INBL cells, HeLa cells
Concentration:	3 μM
Incubation Time:	48 hours
Result:	Markedly reduced the tumor cell number.

Cell Proliferation Assay

Cell Line:	H1299 cells
Concentration:	10 µM, 20 µM, 30 µM, 40 µM, 50 µM
Incubation Time:	24 hours
Result:	Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC₅₀ of 22.9 µM.

Cell Cycle Analysis

Cell Line:	H1299 cells
Concentration:	10 µM, 20 µM, 30 µM, 40 µM, 50 µM
Incubation Time:	24 hours
Result:	Caused the G1 arrest.

Apoptosis Analysis

Cell Line:	H1299 cells
Concentration:	10 µM, 20 µM, 30 µM
Incubation Time:	24 hours, 48 hours
Result:	Increased the level of cleaved caspase-3.

体内研究
(In Vivo)

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8⁺ and CD4⁺ T cell responses to viral infections in virus infected mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice, with lymphocytic choriomeningitis virus infected
Dosage:	0.1 mg/kg
Administration:	Intranasal administration
Result:	Increased the CD8⁺ T cell response to influenza in the lungs.

体内研究

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8⁺ and CD4⁺ T cell responses to viral infections in virus infected mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice, with lymphocytic choriomeningitis virus infected
Dosage:	0.1 mg/kg
Administration:	Intranasal administration
Result:	Increased the CD8⁺ T cell response to influenza in the lungs.

体内研究

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8⁺ and CD4⁺ T cell responses to viral infections in virus infected mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice, with lymphocytic choriomeningitis virus infected
Dosage:	0.1 mg/kg
Administration:	Intranasal administration
Result:	Increased the CD8⁺ T cell response to influenza in the lungs.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (234.91 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3491 mL	11.7456 mL	23.4913 mL
5 mM	0.4698 mL	2.3491 mL	4.6983 mL
10 mM	0.2349 mL	1.1746 mL	2.3491 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献

. Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36. [Content Brief]

. Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19(10): 3010. [Content Brief]

. Curtis J. Pritzl, et al. A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections. J Immunol. 2015 May 1; 194(9): 4339-4349. [Content Brief]

[4]. H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77(3): 1489-1497. [Content Brief]

[5]. Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7;ddaa248. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

安全声明 (欧洲)	S24/25
WGK德国	3
海关编码	2924199090

1. 物质的识别

产品名：	C8-Ceramide
CAS号：	74713-59-0
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	C8-Ceramide
别名：	N-Octanoyl-D-erythro-sphingosine
分子式：	C26H51NO3
分子量：	425.69

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	-20°C, sealed

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。