Carboxyamidotriazole Orotate L-651582 Orotate; CAI Orotate|cas:187739-60-2|西域试剂

Carboxyamidotriazole Orotate L-651582 Orotate; CAI Orotate,98.98%

产品编号：Bellancom-16125| CAS NO：187739-60-2| 分子式：C₂₂H₁₆Cl₃N₇O₆| 分子量：580.76

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货号	价格	库存与货期
Bellancom-16125	￥2000.00	杭州北京（现货）
Bellancom-16125	￥3000.00	杭州北京（现货）
Bellancom-16125	￥5500.00	杭州北京（现货）
Bellancom-16125	￥8500.00	杭州北京（现货）
Bellancom-16125	￥12000.00	杭州北京（现货）

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Carboxyamidotriazole Orotate L-651582 Orotate; CAI Orotate

产品介绍

Carboxyamidotriazole Orotate (L-651582 Orotate)，是一种口服生物有效的信号转导抑制剂Carboxyamidotriazole (CAI) 的 orotate 盐形式。Carboxyamidotriazole Orotate 是一种非电压性钙通道 (nonvoltage-operated calcium channels) 和钙通道介导的信号通路 (calcium channel-mediated signaling pathways) 的细胞抑制剂，具有抗癌，抗炎活性和抗血管生成作用。

生物活性

Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.

体外研究

Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines.
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	LAMA84R and K562R cell lines
Concentration:	0.1, 1, 5, 10 µM
Incubation Time:	24, 48, 72, 96 hours
Result:	Showed a 50% growth reduction of the chronic myelogenous leukaemia (CML) lines with 5 µM CTO at 96 h time point.

Western Blot Analysis

Cell Line:	LAMA84R and K562R cell lines
Concentration:	0.1, 1, 5 µM
Incubation Time:	72 and 96 hours
Result:	A dose-dependent inhibition of both total and phosphorylated Bcr-Abl levels.

体内研究
(In Vivo)

Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male NOD/SCID mice four-to-five week old
Dosage:	342, 513 mg/kg
Administration:	i.p.; Q1D×5 for two rounds
Result:	Increase survival.

体内研究

Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male NOD/SCID mice four-to-five week old
Dosage:	342, 513 mg/kg
Administration:	i.p.; Q1D×5 for two rounds
Result:	Increase survival.

体内研究

Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male NOD/SCID mice four-to-five week old
Dosage:	342, 513 mg/kg
Administration:	i.p.; Q1D×5 for two rounds
Result:	Increase survival.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (8.61 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7219 mL	8.6094 mL	17.2188 mL
5 mM	0.3444 mL	1.7219 mL	3.4438 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献