ANT3310 sodium|cas:2410688-61-6|西域试剂

ANT3310 sodium,99.54%

产品编号：Bellancom-147349| CAS NO：2410688-61-6| 分子式：C₆H₈FN₂NaO₅S| 分子量：262.19

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货号	价格	库存与货期
Bellancom-147349	￥1000.00	杭州北京（现货）
Bellancom-147349	￥1650.00	杭州北京（现货）
Bellancom-147349	￥3450.00	杭州北京（现货）
Bellancom-147349	￥5500.00	杭州北京（现货）
Bellancom-147349	￥9500.00	杭州北京（现货）

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ANT3310 sodium

产品介绍

ANT3310 sodium 是一种广谱的、共价的丝氨酸 β-内酰胺酶 (Serine β-Lactamase) 抑制剂，IC₅₀ 值为 1 nM-175 nM (一系列丝氨酸β-内酰胺酶)。ANT3310 sodium 增强 β-内酰胺类抗生素对耐碳青霉烯类肠杆菌 (CRE) 和鲍曼不动杆菌 (CRAB) 的活性。ANT3310 sodium 可用于细菌感染相关的研究。

生物活性

ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC₅₀ values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). ANT3310 sodium can be used in the research of bacterial infection.

体外研究

ANT3310 sodium (Compound 21, 0.006 to 3 000 nM, 10 min) inhibits a series of Serine β-Lactamase (AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2), with IC₅₀ values ranging from 1 nM to 175 nM.
ANT3310 sodium shows a low in vitro cytotoxicity (IC₅₀: > 100 μM) in HepG2 cell, cardiotoxicity (inhibition of the hERG potassium ion channel), and genotoxicity (Ames test).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

ANT3310 sodium (intravenous injection, 25-100 mg/kg, at 1, 3, 5, and 7 h postinfection) reduces bacterial burdens in murine thigh infection model.
ANT3310 sodium (intravenous injection, 1 mg/kg, Male Swiss albino mice) shows a T_1/2 value of 0.64 h, AUC value of 412 ng•h/mL, and Cl value of 40 mL/min/kg (pharmacokinetic assay).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Murine thigh infection model
Dosage:	25, 50, and 100 mg/kg
Administration:	Intravenous injection, at 1, 3, 5, and 7 h postinfection
Result:	Reduced bacterial burdens (colony forming units, CFU) in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Murine thigh infection model
Dosage:	25, 50, and 100 mg/kg
Administration:	Intravenous injection, at 1, 3, 5, and 7 h postinfection
Result:	Reduced bacterial burdens (colony forming units, CFU) in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (953.51 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8140 mL	19.0701 mL	38.1403 mL
5 mM	0.7628 mL	3.8140 mL	7.6281 mL
10 mM	0.3814 mL	1.9070 mL	3.8140 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式