AzddMeC CS-92|AzddMeC CS-92|cas:87190-79-2|西域试剂

AzddMeC CS-92,AzddMeC CS-92,99%

产品编号：Bellancom-105268| CAS NO：87190-79-2| 分子式：C₁₀H₁₄N₆O₃| 分子量：266.26

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货号	价格	库存与货期
Bellancom-105268	￥2500.00	杭州北京（现货）
Bellancom-105268	￥3600.00	杭州北京（现货）
Bellancom-105268	￥7200.00	杭州北京（现货）

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AzddMeC CS-92

产品介绍

AzddMeC (CS-92) 是一种抗病毒核苷类似物，也是一种有效的，选择性的，具有口服活性的 HIV-1 逆转录酶和 HIV-1复制的抑制剂。在感染 HIV-1的人类 PBM 细胞和感染 HIV-1的人类巨噬细胞中，AzddMeC 的 EC₅₀ 值分别为 9 nM 和 6 nM。

生物活性

AzddMeC (CS-92) is an antiviral nucleoside analogue and a potent potent, selective and orally active HIV-1 reverse transcriptase and HIV-1 replication inhibitor. In HIV-1-infected human PBM cells and HIV-1-infected human macrophages, the EC₅₀ values of AzddMeC are 9 nM and 6 nM, respectively.

体外研究

AzddMeC (CS-92) is also effective against HIV-2 in lymphocytes. The replication of Friend murine virus is only weakly inhibited, and no effect is observed against HSV type 1 and type 2 and coxsackievirus B4. The interaction of the 5'-triphosphate of AzddMeC with HIV-1 reverse transcriptase indicated competitive inhibition (the inhibition constant, Kis, is 9.3 nM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 200 mg/mL (751.15 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7557 mL	18.7786 mL	37.5573 mL
5 mM	0.7511 mL	3.7557 mL	7.5115 mL
10 mM	0.3756 mL	1.8779 mL	3.7557 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献