Lactimidomycin|cas:134869-15-1|西域试剂

Lactimidomycin

产品编号：Bellancom-18979| CAS NO：134869-15-1| 分子式：C₂₆H₃₅NO₆| 分子量：457.56

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-18979		￥9700.00	杭州北京（现货）

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Lactimidomycin

产品介绍

Lactimidomycin 是从链霉菌中分离出的含戊二酰亚胺的化合物。Lactimidomycin 是一种有效的真核翻译延伸抑制剂，对肿瘤细胞系具有有效的抗增殖作用，并选择性抑制蛋白质翻译。Lactimidomycin 抑制蛋白质合成，IC₅₀ 值为 37.82 nM。Lactimidomycin 还是登革热病毒 2 和其他 RNA 病毒的有效且无毒的抑制剂。抗癌和抗病毒活性。

生物活性

Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC₅₀ value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities.

体外研究

Lactimidomycin (0.01-100 nM; 24 hours; Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A) treatment inhibits cell growth with IC₅₀ concentrations in the low nanomolar range, but higher doses are necessary to inhibit growth of the non-tumorigenic breast cell line MCF10A.
Lactimidomycin induces a clear dose-responsive inhibition of DENV2 infectious particle production with an EC₉₀ value of 0.4 μM. No measurable decrease in cell viability was detected at concentrations up to 12.5 µM.
Lactimidomycin is a potent inhibitor of DENV2 and Lactimidomycin's inhibition of DENV2 translation leads to reduced production of newly infectious particles. Lactimidomycin may protect cells from viral cytopathic effects including apoptosis, likely through inhibition of virus protein production and replication.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A
Concentration:	0.01-100 nM
Incubation Time:	24 hours
Result:	Inhibited cell growth with IC₅₀ concentrations in the low nanomolar range.

体内研究
(In Vivo)

Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (6-8 week old) with MDA MB 231 cells
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; daily; for one month
Result:	Had an appreciable effect on tumor growth in vivo.

体内研究

Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (6-8 week old) with MDA MB 231 cells
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; daily; for one month
Result:	Had an appreciable effect on tumor growth in vivo.

体内研究

Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (6-8 week old) with MDA MB 231 cells
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; daily; for one month
Result:	Had an appreciable effect on tumor growth in vivo.