Resmetirom MGL-3196; VIA-3196|cas:920509-32-6|西域试剂

Resmetirom MGL-3196; VIA-3196,99.71%

产品编号：Bellancom-12216| CAS NO：920509-32-6| 分子式：C₁₇H₁₂Cl₂N₆O₄| 分子量：435.22

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-12216	￥600.00	杭州北京（现货）
Bellancom-12216	￥1100.00	杭州北京（现货）
Bellancom-12216	￥1600.00	杭州北京（现货）
Bellancom-12216	￥4400.00	杭州北京（现货）
Bellancom-12216	￥7500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Resmetirom MGL-3196; VIA-3196

产品介绍

Resmetirom (MGL-3196) 是高度选择性的THR-β激动剂，EC₅₀值为0.21 μM。

生物活性

Resmetirom (MGL-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC₅₀ value of 0.21 μM.

体外研究

Resmetirom (MGL-3196) is 28-fold selective for THR-β (EC₅₀=0.21 μM) over THR-α (EC₅₀=3.74 μM ) in a functional assay. Resmetirom (MGL-3196) shows an IC₂₀ of roughly 30 μM for blockage of the hERG channel. The IC₅₀ for CYP3A4/5 and for CYP2C19 is >50 μM, and there is only weak inhibition (roughly 22 μM) of CYP2C9.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Resmetirom (MGL-3196) exhibits good exposures and reasonable oral bioavailability in rats. The volume of distribution and clearance are both low. Dose proportional increases in exposure are observed for a suspension of Resmetirom (MGL-3196) given orally to DIO mice.In animals treated with Resmetirom (MGL-3196) there is a reduction in cholesterol and in liver size, which is secondary to reduction of liver TG. There is no effect on bone mineral density (BMD) or heart or kidney size in Resmetirom (MGL-3196) treated animals.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (287.21 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2977 mL	11.4884 mL	22.9769 mL
5 mM	0.4595 mL	2.2977 mL	4.5954 mL
10 mM	0.2298 mL	1.1488 mL	2.2977 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式